The existing aesthetic QR code algorithms do not consider the region of interest of a background image, which affects the beautification effect. A new aesthetic QR code algorithm based on region of interest and RS code mechanism was proposed. Firstly, an improved region of interest detection algorithm based on multiple features was proposed to get the salient binary image of the background image. Secondly, an intermediate QR code was obtained by performing an XOR operation on the original RS code by using the RS coding matrix, which was completely consistent with the salient binary image of the background image. Then the background image and the intermediate QR code were fused according to a specific fusion method. To further expand the aesthetic area, the RS error correction mechanism was performed on the fusion map, getting the final aesthetic QR code image. Experimental results on the established test sample set show that the proposed aesthetic algorithm can achieve complete background replacement, save more image information, and has a better visual effect and a higher decoding rate.